Monday, March 25, 2019

Buy Soma Online to Treat Muscle Pain

Soma Online

Soma is taken to get relief from discomfort related with acute painful skeletal muscle conditions. This medication should only be administered for short-term treatment with the time period not exceeding three weeks as its effectiveness in the long-term is yet to be established. Further, these painful skeletal muscle conditions are usually of short duration. Buy soma online if you want to avoid the hassle of going to the drug store.

Dosage forms and strengths

This drug is available in the strength of 250 mg and 350 mg tablets. The 250 mg pills are white, convex and round with SOMA 250 inscribed on it. The 350 mg tablets are also white, round and convex with SOMA 350 inscribed on it.

Dosage and administration

The prescribed dose of soma medication is 250 mg to 350 mg thrice a day and before going to bed. You should not take it for more than three weeks.

What are the warnings and precautions associated with soma use?

Soma pain medicine has sedative properties and may also have a detrimental effect on the physical and mental capabilities needed to undertake potentially dangerous activities such as operating heavy machinery and driving a motor vehicle. Post-marketing incidents of motor vehicle accidents related with the use of this drug have been reported.

There is a possibility of sedative effects of soma drug and other CNS depressants such as benzodiazepines, tricyclic antidepressants, alcohol and opioids being additive, extra care should be taken in patients who ingest more than one of the above mentioned CNS depressants simultaneously.

Incidents of withdrawal, dependence and abuse associated with prolonged usage of this medication have been reported in its post-marketing experience. Majority of cases of withdrawal, dependence and abuse are seen in patients either with a history of addiction or who have taken this drug along with other medications having abuse potential. Further, post-marketing adverse effects linked with soma abuse have also been reported when taken in the absence of other medications with abuse potential. Withdrawal reactions are reported when you suddenly discontinue the use after taking it for a long period of time. 

Dependence may also be caused by soma as well as meprobamate, one of its metabolite.

To decrease the probability of soma withdrawal, dependence or abuse, it should be administered with care in patients prone to addiction and who take other CNS depressants such as alcohol. It should also not be given for a time duration exceeding three weeks to relieve the symptoms of acute painful musculoskeletal discomfort.

Seizures have also been reported in patients who are taking soma medicine. May of such incidents have taken place during multiple drug overdose including illegal drugs, drugs of abuse and alcohol.

What are the side effects associated with soma use?

If you do not ingest this drug in the exact manner as prescribed, it may lead to the occurrence of harmful side effects. These include:
  1. Central nervous system: dizziness, ataxia, drowsiness, vertigo, tremors, irritability, agitation, headache, syncope, seizures, depressive reactions and insomnia.
  2. Hematologic: pancytopenia, leukopenia
  3. Cardiovascular: postural hypotension, tachycardia, facial flushing
  4. Gastrointestinal: vomiting, epigastric discomfort

 
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Drug interactions with soma:

There is a probability of the sedative effects of this drug as well as other CNS depressants such as benzodiazepines, tricyclic antidepressants, alcohol and opioids being additive. Hence, care should be taken with patients who ingest more than one of these CNS depressants together with soma pills. It is not advisable to take this medication with its metabolite, meprobamate.

Carisoprodol is broken down in the liver to form meprobamate by CYP2C19. 
Simultaneous administration of CYP2C19 inhibitors, for example, fluvoxamine or omeprazole with soma may lead to reduced exposure of meprobamate and greater exposure of carisoprodol. Similarly, simultaneous administration CYP2C19 inducers, for example, St. John’s Wort or rifampin with this drug may lead to greater exposure of meprobamate and lower exposure of carisoprodol. Induction effect on CYP2C19 was also showed by low dose aspirin.

Use of soma in pregnant women

There is no research data on the usage of this medication in human pregnancy. However, animal studies show that carisoprodol, the muscle relaxant, cross the placenta and causes harmful effects on postnatal survival and fetal growth. Meprobamate, the main metabolite of carisoprodol is an approved anxiolytic.
Any consistent linkage between maternal usage of meprobamate and a greater risk for specific congenital malformations has not been seen in retrospective, post-marketing studies. 

Animal studies have not satisfactorily assessed carisoprodol’s teratogenic effects. No increase was seen in the incidence of congenital malformations observed in reproductive studies in rabbits, rats and mice that were treated with meprobamate. Retrospective, post-marketing studies of carisoprodol metabolite, meprobamate, in human pregnancy were evasive for showing a greater risk of congenital malformations in the first three months. The types of malformations were not consistent throughout studies that showed a higher risk.

In animal studies, carisoprodol decreased postnatal weight gain, fetal weights and also postnatal survival at a maternal dosage equal to 1-1.5 times the human dosage. Behavioral changes that continued to adulthood were seen in rats exposed to meprobamate in-utero. It is advisable to take soma drug during pregnancy only it if probable benefit justifies the risk posed to the fetus.

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